CONSENSUS CONFERENCE: USE OF OZONE IN THE CONTEXT OF REGENERATIVE MEDICINE. RECOMMENDATIONS FROM THE ITALIAN SOCIETY OF MULTI-SPECIALIST REGENERATIVE MEDICINE AND SURGERY (SIMCRI)
Running head: Consensus Conferences SIMCRI Ozone
M.A. Farina1, G. Martínez-Sánchez2,3*, Massimo Danese4, A. Alexandre5, g. Caloprisco6, R. Miranda7, F.J. Tallón-Hidalgo8, G. Tabaracci9, M. Malatesta10, M. Vásquez Bravo11, R. Thiele12, D. Apuzzo13, F. Giacinto14, V. Di Donna15, S. di Biagio16, C.A. Morales-Portillo17, G. Francioni18, R. Mancusi19, F.S.M. Araimo-Morselli20, R. Cardelli21, N. Dardes22, R. Saggini23, F. Alvarado-Güemez24, J.U. Cachay-Agurto25, L. Rojas-González26, R. Venegas-Flores27, M. Bonetti28, E. Farina29, F. Monea30, G. Manfredi31, C. Tavera32, A. Izzo33, A. Bertolotti34, M. Martínez Castillo35, M. Martinelli36, A. Turchi37, G. Valletta38, C. Lopes Guerreiro39 and E. Luigi Iorio40
1Vascular Surgeon. Caserta. Italy; SIMCRI Honorary President;
2Freelance Scientific Advisor, Ancona, Italy;
3Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria, Spain;
4Specialist in General Surgery and Vascular Surgery, San Giovanni Addolorata Hospital, Roma, Italy;
5European Institute of Neurosurgery, Treviso, Italy;
6Hematologist, Belluno, Italy;
7SIMCRI Scientific Advisor, Vascular Surgeon, Naples, Italy;
8Institute of Neurosciences of the University of Granada, Granada, Spain;
9San Rocco Clinic, Montichiari (BS), Italy;
10Department of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section, University of Verona, Italy;
11President of the Peruvian Society of Ozone Therapy and Regenerative Medicine, Lima, Peru;
12Vice President Austrian Ozone Therapy Association, Leonding, Upper Austria;
13President of International Academy of Ozone Therapy Research (AIRO), Roma, Italy;
14National Councillor of the Italian Association of Skin Ulcers, Cosenza, Italy;
15Dama Salus Medical Center – Trani (BT), Italy;
16Medical Surgeon Specialist in Odontostomatology, Roma, Italy;
17Specialist in Anesthesiology and Pain Management, Inst. Med. CAMP, Málaga, Spain;
18Chief surgeon, Nuova Ricerca Private Hospital, Rimini Italy;
19Specialist in Vascular Surgery, Ischia Vascular Institute, Ischia, Italy;
20Department of Anesthesia and Resuscitation. Umberto I University Hospital, Rome, Italy;
21Physiotherapy and Physical Therapy Clinic, Bologna, Italy;
22Pulmonologist and Internist, Intramedica, Roma Italy;
23Specialist in Orthopedics and Traumatology, Physical Therapy and Rehabilitation and Sports Medicine, Rome, Italy;
24President of the Mexican Association of Ozone Therapy, Culiacán, Mexico;
25Vice-President of the Peruvian Society of Ozone Therapy and Regenerative Medicine, Chimbote, Perú;
26President of the Mexican Society of Ozone Therapy and Regenerative Medicine, Puebla, Mexico;
27Vice-President of the Mexican Society of Ozone Therapy and Regenerative Medicine, Puebla, Mexico;
28Neuroradiologist, Oberdan Polyclinic, Bescia, Italy;
29Vascular Surgery, Caserta, Italy;
30Physiatrist, Monea Polyclinic, Reggio Calabria, Italy;
31Allergist, Bari, Italy;
32Sports Medicine Specialist, Como, Italy;
33Medical Consultant, Cremona, Italy;
34Psychiatrist, Brescia, Italy;
35General Practitioner, Biomedical, San Pedro Sula, Honduras;
36Department of Biomedical Sciences, Ozone Therapy Unit, Ospedale San Pietro Fatebenefratelli, Roma, Italy;
37Aesthetic Doctor, Artemisia Lab, Roma, Italy;
38Orthopedic Traumatologist, Naples, Italy;
39Member of Portuguese Ozone Therapy Society, Portugal;
40President of the International Observatory of Oxidative Stress, Italy;
Correspondence to:
Gregorio Martínez-Sánchez, MD
Freelance Scientific Advisor, Ancona, Italy;
Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC),
Las Palmas de Gran Canaria, Spain
e-mail: gregorcuba@yahoo.it
| Received: 01 March, 2026 Accepted: 24 March, 2026  |
ISSN 2975-044X (online) ISSN 2038-4106 (print) Copyright © by LAB PUBLISHERS 2026 This publication and/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties. Disclosure: All authors report no conflicts of interest relevant to this article. |
ABSTRACT
This paper summarizes the final pronouncement of the Consensus Conference on “Use of Ozone in Regenerative Medicine” and discusses the integration of ozone therapy (OT) in clinical practice based on current scientific knowledge and clinical experience. Organized by the Italian Society of Multi-Specialist Regenerative Medicine and Surgery (SIMCRI), the consensus meeting brought together expert clinicians and researchers to explore OT’s mechanisms, indications, contraindications, clinical protocols, and potential adverse reactions. Key aspects addressed included evaluating the effectiveness of OT in vulnology and for degenerative joint disorders and its combination with Platelet Rich Plasma (PRP). Efficacy assessment criteria were based on evidence-based medicine. The consensus concluded that local or systemic OT is both safe and effective, particularly for challenging ulcers and some degenerative osteoarticular conditions. Additionally, combining PRP with ozone may enhance reparative processes without adverse effects. Ozone’s ability to improve circulation, reduce oxidative stress and inflammation, and counteract hypoxia complements PRP in tissue regeneration. However, while these findings are promising, the available literature remains limited and of low evidence quality. The consensus recommends further multidisciplinary studies to establish OT as a clinical practice, especially for conditions like diabetic foot, where combined ozone and PRP therapies could provide significant therapeutic benefits.
KEYWORDS: ozone therapy, regenerative medicine, consensus conference, platelet-rich plasma