{"id":20553,"date":"2022-10-13T12:13:30","date_gmt":"2022-10-13T10:13:30","guid":{"rendered":"https:\/\/www.biolife-publisher.it\/ejmd\/?p=20553"},"modified":"2024-05-24T11:41:25","modified_gmt":"2024-05-24T09:41:25","slug":"the-effect-of-hyaluronic-acid-on-human-fibroblasts-an-in-vitro-study","status":"publish","type":"post","link":"https:\/\/www.labpublishers.com\/ejmd\/the-effect-of-hyaluronic-acid-on-human-fibroblasts-an-in-vitro-study\/","title":{"rendered":"THE EFFECT OF HYALURONIC ACID ON HUMAN FIBROBLASTS: AN IN VITRO STUDY"},"content":{"rendered":"<p style=\"text-align: justify;\">A. Palmieri<sup>1<\/sup>, P. Daliu<sup>2 <\/sup>and E. Qorri<sup>2<\/sup><\/p>\n<p style=\"text-align: justify;\"><sup>1<\/sup>Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy<br \/>\n<sup>2<\/sup>Dental School, Albanian University, Tirana, Albany<\/p>\n<p style=\"text-align: justify;\"><em>Correspondence to:<\/em><\/p>\n<p style=\"text-align: justify;\">Annalisa Palmieri, PhD<br \/>\nDepartment of Experimental, Diagnostic and Specialty Medicine,<br \/>\nUniversity of Bologna, Bologna, Italy<br \/>\ne-mail: <a href=\"mailto:annalisa.palmieri@unibo.it\">annalisa.palmieri@unibo.it<\/a><\/p>\n<table style=\"width: 100.666%;\">\n<tbody>\n<tr>\n<td style=\"width: 47.2289%;\">Received: 23 June, 2021<br \/>\nAccepted: 17 August, 2021<strong><a href=\"https:\/\/www.labpublishers.com\/ejmd\/wp-content\/uploads\/2022\/10\/6.-Palmieri-1_final_evaluation-study.pdf\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-20149 size-full\" src=\"https:\/\/www.labpublishers.com\/ejmd\/wp-content\/uploads\/2022\/07\/pdf-download-e1659347963440.jpg\" alt=\"\" width=\"110\" height=\"112\" \/><\/a>Copyright:<\/strong><br \/>\nBiolife-Publisher.it \u00a9 2021<\/td>\n<td style=\"width: 57.8313%;\">\n<p style=\"text-align: right;\">ISSN: 2038-4106<\/p>\n<p style=\"text-align: right;\">This publication and\/or article is for individual use only and may not be further reproduced without written permission from the copyright holder. Unauthorized reproduction may result in financial and other penalties.<\/p>\n<p style=\"text-align: right;\"><em>Disclosure: All authors report no conflicts of interest relevant to this article.<\/em><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"text-align: justify;\"><strong>ABSTRACT<\/strong><\/p>\n<p style=\"text-align: justify;\">The linear glycosaminoglycan hyaluronic acid is a component of many body organs and tissues, such as the extracellular matrix of connective tissue, skin, synovial fluid, and embryonic mesenchymal tissue, naturally occurring with a high molecular weight. Hyaluronic acid can also be detected in the soft periodontal tissues (gingiva and periodontal ligament). Hyaluronic acid biocompatibility, biodegradability, non-toxicity, non-immunogenic and non-inflammatory properties make it applicable to bioengineering and biomedicine fields. Its molecular weight influences the biological effects of hyaluronic acid.\u00a0High-molecular weight hyaluronic acid causes the suppression of immune response, avoiding the exacerbations of inflammation; on the other hand, low-molecular-weight hyaluronic acid takes part in tissue damage signaling and immune cell mobilization. Thanks to these properties, hyaluronic acid can be considered a promoter of soft tissue and bone healing.\u00a0This study evaluates the effect of hyaluronic acid with different molecular weights on fibroblasts.<\/p>\n<p style=\"text-align: justify;\"><strong>Keywords: <\/strong><em>hyaluronic acid, inflammation, fibroblasts<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A. Palmieri1, P. Daliu2 and E. Qorri2 1Department of Experimental,&#46;&#46;&#46;<\/p>\n","protected":false},"author":1036,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[2500],"tags":[797,642,154],"class_list":["post-20553","post","type-post","status-publish","format-standard","hentry","category-ejmd-vol-10-issue-2-jul-dec-2021","tag-fibroblasts","tag-hyaluronic-acid","tag-inflammation"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>THE EFFECT OF HYALURONIC ACID ON HUMAN FIBROBLASTS: AN IN VITRO STUDY - LAB Publishers - Scientific Publisher<\/title>\n<meta name=\"description\" content=\"Lab Publishers is a leading scientific publisher dedicated to advancing medical research worldwide. 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