CONSENSUS CONFERENCE: USE OF OZONE IN THE CONTEXT OF REGENERATIVE MEDICINE. RECOMMENDATIONS FROM THE ITALIAN SOCIETY OF MULTI-SPECIALIST REGENERATIVE MEDICINE AND SURGERY (SIMCRI)

¹ Vascular Surgeon. Caserta. Italy; SIMCRI Honorary President
² Freelance Scientific Advisor, Ancona, Italy; Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria, Spain
³ Specialist in General Surgery and Vascular Surgery, San Giovanni Addolorata Hospital, Roma, Italy
⁴ European Institute of Neurosurgery, Treviso, Italy
⁵ Hematologist, Belluno, Italy
⁶ SIMCRI Scientific Advisor, Vascular Surgeon, Naples, Italy
⁷ Institute of Neurosciences of the University of Granada, Granada, Spain
⁸ San Rocco Clinic, Montichiari (BS), Italy
⁹ Department of Neurosciences, Biomedicine and Movement Sciences, Anatomy and Histology Section, University of Verona, Italy
¹⁰ President of the Peruvian Society of Ozone Therapy and Regenerative Medicine, Lima, Peru
¹¹ Vice President Austrian Ozone Therapy Association, Leonding, Upper Austria
¹² President of International Academy of Ozone Therapy Research (AIRO), Roma, Italy
¹³ National Councillor of the Italian Association of Skin Ulcers, Cosenza, Italy
¹⁴ Dama Salus Medical Center - Trani (BT), Italy
¹⁵ Medical Surgeon Specialist in Odontostomatology, Roma, Italy
¹⁶ Specialist in Anesthesiology and Pain Management, Inst. Med. CAMP, Málaga, Spain
¹⁷ Chief surgeon, Nuova Ricerca Private Hospital, Rimini Italy
¹⁸ Specialist in Vascular Surgery, Ischia Vascular Institute, Ischia, Italy
¹⁹ Department of Anesthesia and Resuscitation. Umberto I University Hospital, Rome, Italy
²⁰ Physiotherapy and Physical Therapy Clinic, Bologna, Italy
²¹ Pulmonologist and Internist, Intramedica, Roma Italy
²² Specialist in Orthopedics and Traumatology, Physical Therapy and Rehabilitation and Sports Medicine, Rome, Italy
²³ President of the Mexican Association of Ozone Therapy, Culiacán, Mexico
²⁴ Vice-President of the Peruvian Society of Ozone Therapy and Regenerative Medicine, Chimbote, Perú
²⁵ President of the Mexican Society of Ozone Therapy and Regenerative Medicine, Puebla, Mexico
²⁶ Vice-President of the Mexican Society of Ozone Therapy and Regenerative Medicine, Puebla, Mexico
²⁷ Neuroradiologist, Oberdan Polyclinic, Bescia, Italy
²⁸ Vascular Surgery, Caserta, Italy
²⁹ Physiatrist, Monea Polyclinic, Reggio Calabria, Italy
³⁰ Allergist, Bari, Italy
³¹ Sports Medicine Specialist, Como, Italy
³² Internal Doctor, Cremona, Italy
³³ Psychiatrist, Brescia, Italy
³⁴ General Practitioner, Biomedical, San Pedro Sula, Honduras
³⁵ Department of Biomedical Sciences, Ozone Therapy Unit, Ospedale San Pietro Fatebenefratelli, Roma, Italy
³⁶ Aesthetic Doctor, Artemisia Lab, Roma, Italy
³⁷ Orthopedic Traumatologist, Naples, Italy
³⁸ Member of Portuguese Ozone Therapy Society, Portugal
³⁹ President of the International Observatory of Oxidative Stress, Italy

Correspondence to:

European Journal of Musculoskeletal Diseases 2026 May-August 15(2): 96-110
https://doi.org/10.82093/ejmd/2026v15iss2_5

Received: 15 June 2026 Accepted: 23 July 2026

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Abstract

This paper summarizes the final pronouncement of the Consensus Conference on “Use of Ozone in Regenerative Medicine” and discusses the integration of ozone therapy (OT) in clinical practice based on current scientific knowledge and clinical experience. Organized by the Italian Society of Multi-Specialist Regenerative Medicine and Surgery (SIMCRI), the consensus meeting brought together expert clinicians and researchers to explore OT’s mechanisms, indications, contraindications, clinical protocols, and potential adverse reactions. Key aspects addressed included evaluating the effectiveness of OT in vulnology and for degenerative joint disorders and its combination with Platelet Rich Plasma (PRP). Efficacy assessment criteria were based on evidence-based medicine. The consensus concluded that local or systemic OT is both safe and effective, particularly for challenging ulcers and some degenerative osteoarticular conditions. Additionally, combining PRP with ozone may enhance reparative processes without adverse effects. Ozone’s ability to improve circulation, reduce oxidative stress and inflammation, and counteract hypoxia complements PRP in tissue regeneration. However, while these findings are promising, the available literature remains limited and of low evidence quality. The consensus recommends further multidisciplinary studies to establish OT as a clinical practice, especially for conditions like diabetic foot, where combined ozone and PRP therapies could provide significant therapeutic benefits.

Keywords: consensus conference, Ozone therapy, platelet-rich plasma, regenerative medicine